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Contribution | TU-Eindhoven - iGEM 2024

Contribution

If you have knowledge, let others light their candles in it.

~ Margaret Fuller

Seeking knowledge from others' experiences is one of the most valuable resources for current iGEM teams. Building on and learning from the ideas of others is fundamental to scientific progress. For this reason, our team has made an effort to document our challenges and the solutions we developed, so that future teams can benefit from our experiences and avoid similar mistakes.


Sponsorship tips

We organized an online interactive session with many iGEM teams to exchange ideas on achieving funding. We shared our experiences but mainly let people pitch their project and get feedback from the other teams. You can read more about this session on the collaborations page.

We wrote down the tips that were shared during this session to help future iGEM teams as well. You can find these tips in our handout below. The iGEM community manager has expressed that they want to share this document in the next iGEM cycle.

collaboration-photo
Figure 1: Screenshot taken during the session.

Making bioinformatics user-friendly

Bioinformatics tools are often difficult to use. They are usually command-line based and require many manual steps. We have created a pipeline software that makes bioinformatics more user-friendly. Our software has a web interface that allows for inspection of the process and results. A screenshot of the pipeline visualization can be seen on the right. Installation is easy and it can be run on any platform. We designed the software to be modular, so you can easily add new tools and create new pipelines for a different application. More information can be found on the modeling page.

When getting started with (cancer) bioinformatics analysis, we recommend following the tutorials by Griffith lab. These tutorials take you from no prior knowledge to a full understanding, enabling you to expand on our project. All steps are explained in detail and you can follow along with the provided data.

While developing this software, we identified and reported several bugs in the tools we utilized, such as pVACtools and VAtools. Some of these bugs were fixed by the developers, allowing us to contribute to the open-source community. Moreover, we reported issues in the open source software we used which were fixed by the developers.

Figure 3: Screenshot of the pipeline vizualisation.

How to organize an event

During our iGEM journey we organized different events, namely the iGEM pubquiz for the general public, the Challenge day for high schools students and the Mini Jamboree for other iGEM teams. We have learned a lot from organizing these events and would love to share our experience and approach, so future iGEM teams could get inspired and built upon it. In the drop-downs below, you can find manuals for all three events. Feel free to use them whenever you need!