Plklfc

P-Cas

Prostate_Cancer

Second most common cancer in men
1.5 Million new cases in 2022

Both sexes

Incidence

20.0 million
new cases

Mortality

9.7 million
deaths

400 Thousand people suffer from death due to prostate cancer
Five-year survival rate for prostate cancer in Stage IV is just 45%
Most people cannot discover prostate cancer at an early stage as the tumors developed with no obvious symptoms in the early stage

Males

Incidence

10.3 million
new cases

Mortality

5.4 million
deaths

Making improvements to make the detection of prostate cancer become more accurate and simple

Adding a new function: Killing prostate cancer cells

PSMA will be the biomarker of our project A plasmid is designed for detecting and killing prostate cancer cells

Polymer will be used to deliver the plasmid to the prostate

Aptamers will be attached on the surface of the polymer

Aptamers will bind to the prostate cancer cells to release the plasmid

The plasmid will be expressed under high PSMA level and produce a fluorescence protein called Gaussia Luciferase, GluC

GluC will return to the bloodstream

Urine will be collected and the amount of GluC will be measured, and prostate cancer is detected

Expression of plasmid will also produce another protein called Bax, an apoptosis regulator

Bax will trigger prostate cancer cells to undergo apoptosis, and prostate cancer is cured