Swimmimg tunnel for zebrafish larvae:

Idea

The swimming tunnel is a commonly used device for measuring cardiovascular indicators in fish. Based on this concept, we have envisioned a swimming tunnel for zebrafish larvae. According to literature, 5-day post-fertilization (dpf) zebrafish larvae already exhibit an instinct for swimming against the current. This instinct can help us better understand whether larvae in the PD model exhibit symptoms of sudden muscle stiffness, similar to how human patients may have a switch-like reaction after medication effects wear off.

Design

We aim to design the swimming tunnel for larvae with an extremely small diameter to prevent the fish from turning around or exhibiting other complex behaviors that could affect endurance and skew results regarding Parkinson’s symptoms.

The road not taken

However, due to a lack of manpower, this project has not yet been successfully implemented and remains at the hypothesis stage. We are very much looking forward to future teams utilizing this idea to accelerate experimental cycles, ultimately benefiting human patients with neurodegenerative diseases.