-LANTERN-
LANTERN
Programmable Logic Framework
Based on Recombinase and CRISPR Interference
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Inspired by programmable logic devices (PLD), we've designed a programmable synthetic biology pathway that allows you to customize the logic gates you need for your specific scenarios.
Why named LANTERN?
0 & 1 are the most common elements in logic gates, and we found shapes of “0” and “1” can perfectly form the pattern of a traditional Chinese lantern.
With the help of recombinases and CRISPRi, LANTERN can switch between different types of logic gates based on user requirements.To enhance recombinase efficiency, we designed a directed evolution system and obtained better recombinase.
By simply changing the inputs and output according to your requirements, LANTERN can transfer into whatever logic gate you want. Our design meets the need to obtain different logical relationships in the lab and has prospective application in industry manufacturing. Additionally, our project introduces a new concept of "programmable pathway synthetic biology", aiming to draw more inspiration from electronic circuits and contribute to the future development of synthetic biology.
