After opening the local Prometheus frontend (or accessing the Prometheus online frontend at igem.iamdanny.online), you'll find buttons at the top of the left navigation bar to switch between Expert Mode and Freshman Mode. Click to switch to the corresponding mode. Note: Switching pages will clear all cached data and conversation history.

At the bottom of the navigation bar, there's a button to go to the Feedback page. Click it to switch to the Feedback page and provide feedback to us. We will carefully read the feedback provided by users and use it to improve our model.

The main part of the page is divided into two sections: the left side is the user input interface, where we have designed two different input methods for Freshman Mode and Expert Mode. The right side is the model's output interface, which includes feedback on component matching results and recommendations for the best components. When conditions are appropriate, it will also provide users with a complete plasmid assembled based on their description.

When displaying the model's search results, Prometheus will separately show the top 10 best components obtained from querying each of the user's requirements, placing the optimal component selected by Llama 3 at the top and additionally displaying its sequence. Each component will list its name, function, usage environment, and a link to the official iGEM database. Additionally, there's a rating system beneath each component's name, allowing users to rate it based on their level of approval. The collected data will be used for subsequent improvements and fine-tuning of the Prometheus model.

In Freshman Mode, users can input content in the text box at the bottom of the input interface, just like using other large language models, and have a natural language conversation with Prometheus. Prometheus will gradually guide the user until it can extract a formatted description of the user's desired functionality. Then, Prometheus will display the extracted information to the user and allow them to query Prometheus's database with one click to match the components and plasmids that best meet their requirements.

We demonstrate a complete use of Freshman Mode in the following GIF.

In contrast to Freshman Mode, Expert Mode is designed for users with a certain foundation in synthetic biology to save their time and improve the accuracy and professionalism of descriptions. In Expert Mode, users can freely add the components they need and provide natural language descriptions for them. Prometheus can directly process these formatted descriptions and return search results.

We demonstrate a complete use of Expert Mode in the following GIF.

After the user initiates a query, Prometheus will provide a complete plasmid containing promoters, terminators, functional components, and other necessary elements based on the user's specific requirements for functional components, displaying it in a visual form. After executing the query, the words "Show Plasmid" will appear in the upper right corner of the page. Clicking it will pop up a floating window on the right side of the page, containing Prometheus's complete drawing of the plasmid and detailed explanations of the components. For layout considerations, we will truncate overly long description texts. If users wish to view the full description, they can search the iGEM database using the component names.

We demonstrate a use of Plasmid Display in the following GIF.