Virginia iGEM

Currently Under Construction

What is BLISS?

The Bacillus Lipase Integrated Secretion System (BLISS) is a groundbreaking probiotic developed to address Exocrine Pancreatic Insufficiency (EPI). Through genetic engineering, B. subtilis has been modified to produce human pancreatic lipases, procolipases, amylases, and proteases, functioning as a pancreatic enzyme replacement therapy.

0

individuals worldwide suffer from chronic pancreatitis.

50%

of individuals with chronic pancreatitis develop EPI

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individuals worldwide suffer from cystic fibrosis.

75%

of cystic fibrosis patients develop EPI

0

individuals worldwide suffer from Type 1 Diabetes.

90%

of Type 1 Diabetes patients develop EPI

Individuals with EPI suffer from a deficiency in digestive enzymes and are thus unable to hydrolyze and break down food into nutrients for the body. This can lead to severe malnutrition for EPI patients, resulting in long-term complications including arrhythmia, anemia, and osteoporosis.