Abstract
A soothing nasal suction complex, no taboos for you to ride a roller coaster!
Riding a roller coaster is a thrilling entertainment activity, however, several adverse reactions occur after this game, such as dizziness, vomiting, head tremors, and high heart rate. In addition, activities related with vestibular functions including riding, boating and bungee jumping would also bring the similar side effects.
Usually, people need to cultivate for many days after experiencing short-term excitement, even in severe cases, it is necessary to go to the hospital for treatment. Based on our recent invivo studies, vitamin B6 and B12 take nourishing effects on neurons and vestibular functional areas, which is manifested as relieving the symptoms of neuron oedema, and then eliminating the injuries of key functional areas (vision, hearing and taste), mainly through increasing the permeability of vascular endothelial cells and regulating special signal pathways.
Therefore, in the present project, we plan to research and develop a soothing nasal suction complex to minimize vestibular function damages of intense activities, specially stimulations on the cerebral cortex and neurons by roller coasters. Through constructing intracellular pressurism models of neurons induced by physical or chemical intervention, the effects of vitamin B6, vitamin B12 and their combinations in alleviating cell injuries are primarily evaluated, and the best optimal ratio of two vitamins are screened out. Then, by wrapping with special transmitters, the pharmacokinetic characteristics of the vitamins combination are investigated in cells, and the molecular mechanism is further validated.
With future use feedback gathering, we hope to create an effective and convenient remedy for roller coaster-related discomfort.
Introduction
Frontibul dysfunction, also called unilateral external prefrontal dysfunction, affects one side of the vestibular system and part of the inner ear. This type of dysfunction includes various conditions such as benign paroxysmal positional vertigo, vestibular neuritis, inner otitis, unilateral Meniere’s disease, or postoperative vestibular issues. People with vestibular dysfunction commonly experience dizziness and disturbances in vision, balance, or movement. Aside from physical symptoms, vestibular patients may also experience inattention, memory problems, and mental fatigue at a psychological level. Due to the fear of falling and losing independence, many vestibular patients also struggle with anxiety and depression, significantly impacting their quality of life. The prevalence of these issues is more widespread than we think. According to a survey by Pub MED, dizziness, including vertigo, affects around 15% to over 20% of adults annually in large-scale population-based research. Vestibular vertigo accounts for about a quarter of dizziness cases, with a 5% prevalence over 12 months and an annual incidence of 1.4%. And its actually not that far from our lives……
Project Background
Last year, some of our team members experienced extreme discomfort after riding a roller coaster in Beijing's Happy Valley. After preliminary research, we aware that the symptoms were related to vestibular dysfunction, similar to air sicknesses seasickness and motion sickness and its core mechanism involves the regulation of brain neurons against edema and changes in vascular endothelial permeability. This experience inspired our project concept. Further research revealed that current drugs can only alleviate symptoms but don't address the root cause of motion sickness since they generally lack the protection and repair function of neurons themselves.. Our team want to develop an innovative solution: In the big picture, we aim to design a nasal spray that uses nanomaterials to encapsulate vitamin B6 or B12 into human bodies to increase neuron viabilities and thus minimise swelling after impactful events. Specifically, our product is tailored for everyone seeking a better roller coaster experience, including people of different ages. Our spray might also target another group of people—those with their blood-brain barriers damaged: nasal administration of VB bypasses the BBB, significantly increasing the bioavailability of B vitamins in the brain.
Project Goals
Neuronal swelling can squeeze important areas of your brains and lead to more serious problems if not properly addressed. Therefore, in the long run, we are not only designing this spray for profits, but also ensuring that every roller coaster rider can have access to this harmless material at low prices, and thus eliminate the health risks associate with the fun, enticing roller coasters.