Team Heidelberg

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Engineering genomes
in the third dimension

The cells in our body come in many forms and functions despite sharing the same genomic sequence.

The DNA sequence is only the first dimension of how life is encoded.

The 3D structure of the genome

PLACEHOLDER PLACEHOLDER

determines the interpretation of the sequence.

plays a role in the distinction between humans and the great apes.

can make the difference between health and disease.

Although the 3D genome organization is intensively studied,
it remains nearly impossible to engineer.

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That is why we introduce

PICasSO

and its Digital Twin

DaVinci

Our Toolbox allows to:

Program any DNA-DNA interaction of your choice using our extensive part collection.

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Investigate and prevent disease related genome rearrangements, such as enhancer hijacking in cancer.

Precisely model the interactions in silico for rapid adaption in the wet lab.

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Enable the next generation of scientists.

With PICasSO you can

Bring Genome Engineering
to a new Dimension

Project Description

Find the details here

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Results

See what we discovered

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Model

Learn how DaVinci supports PICasSO

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Education

How we enable the next generation

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Part Collection

Get to know our parts

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