Ursolic Acid (UA) is a natural product found to have anti-cancer properties, specifically in breast cancer
The problem? It is typically produced via fruit extraction, a timely and environmentally taxing process
To combat these issues, a biosynthetic production of UA was developed using gene knock-out and triple homologous recombination.
We designed a bioreactor and biosensor in conjunction, to mass produce Ursolic Acid with live tracking
Post-purification, the Ursolic Acid can be encapsulated utilizing a high specificity encapsulation method composed of beta-cyclodextrin and sEV-liposomes fusion.
With optimization being the goal, we took network-level and enzymatic-level models to target our design approach
With the prominence of UA rising in oncology, the ability to supply pharmaceutical companies with a better production method is crucial to getting UA to cancer patients
