Parts

Introduction to COALES Parts

As part of our iGEM project, we have designed and characterized a set of biological parts that contribute to the core functions of our drug delivery system. Each part is a carefully engineered segment of DNA that performs specific roles, such as specific binding with the cancer cell, escaping endosomal degradation, or release of drug at a certain pH range. These parts are designed to be modular, following the BioBrick standard, allowing them to be easily assembled and integrated into different biological systems.

Our collection includes foundational elements like protein domains and linkers as well as more complex composite parts that combine multiple functions. We aim to ensure that each part is not only functional but also thoroughly characterized, providing valuable tools for future iGEM teams and researchers in the synthetic biology community.

New Basic Parts
Name Part Number Type Link
p160 Tumor Homing peptide BBa_K5137000 Protein domain https://parts.igem.org/Part:BBa_K5137000
PMAP BBa_K5137005 Protein domain https://parts.igem.org/Part:BBa_K5137005
Endosomal protease cleavage site BBa_K5137007 Protein domain https://parts.igem.org/Part:BBa_K5137007
SMT3 BBa_K5137001 Protein domain https://parts.igem.org/Part:BBa_K5137001
mfp1 BBa_K5137002 Protein domain https://parts.igem.org/Part:BBa_K5137002
Linker for TV1 BBa_K5137003 Protein domain https://parts.igem.org/Part:BBa_K5137003
SpyTag 002 BBa_K5137004 Protein domain https://parts.igem.org/Part:BBa_K5137004
SpyCatcher002 BBa_K5137006 Protein domain https://parts.igem.org/Part:BBa_K5137006
ADF3 BBa_K5137008 Protein domain https://parts.igem.org/Part:BBa_K5137008
Linker for CfaN BBa_K5137010 Protein domain https://parts.igem.org/Part:BBa_K5137010
CfaN BBa_K5137011 Protein domain https://parts.igem.org/Part:BBa_K5137011
CfaC BBa_K5137013 Protein domain https://parts.igem.org/Part:BBa_K5137013
CGG-repeat BBa_K5137015 Protein domain https://parts.igem.org/Part:BBa_K5137015
Reused Basic Parts
Name Part Number Type Link
Hexahistidine-tag BBa_K1362468 Tag https://parts.igem.org/Part:BBa_K1362468
New Composite Parts
Name Part Number Type Link
Target component (alternatively named as pYY8aTV1) BBa_K5137500 Composite https://parts.igem.org/Part:BBa_K5137500
Drug Component (alternatively names as pYY3c-L-CfaN) BBa_K5137501 Composite https://parts.igem.org/Part:BBa_K5137501
Drug payload (alternatively named as pCfaC-CGG8) BBa_K5137502 Composite https://parts.igem.org/Part:BBa_K5137502