Gastric cancer is one of the leading causes of cancer-related death worldwide. Ras‐GTPase‐activating protein SH3 domain binding protein1 (G3BP1) is the first RasGAP SH3 domain binding protein. G3BP1 has been reported to be upregulated in gastric cancer tissues and strongly associated with the survival rate of the patients suffering from gastric cancer. G3BP1 protein could directly regulate the mRNA decay through interacting with the highly structure in the 3’-untranslated region (3’UTR). Our project plans to create a sensor containing highly structured 3’UTR to monitor the change of G3BP1, which may provide a novel method to diagnosis gastric cancer at the earlier stages in the future.