The Future of RNA Pesticides

When discussing the development of pesticides in general, we typically separate the discussions of the active ingredient and the drug delivery system (DDS). In chemical pesticide development, discovering an effective active ingredient is extremely challenging and consumes significant time and effort. Conversely, once the active ingredient is identified, discussions about the DDS progress relatively smoothly.

In the case of RNA pesticides, the approach differs from that of chemical pesticides. The RNA sequences, which are the active ingredients, can be relatively easily discovered from genomic information. However, discussions around the DDS are more complex. We must consider methods that enhance sustainability while enabling efficient mass production.

We envision a future where information on RNA interference becomes open source, and companies fiercely compete in the realm of DDS. This is because, while the information on RNA interference remains scientifically constant, DDS represents an area where each company’s technological advantages and patents are less likely to be overturned.

MOVE aims to build an RNA pesticide delivery system that pioneers such a future. To function as a robust RNA pesticide platform, we are simultaneously developing software that connects information on various crops and RNA pesticides, which have not yet been integrated.

Schedule

1. Confirmation of Efficacy in Laboratory Conditions
   1. Efficacy Tests
      • Evaluation of RNA interference effects against pests and pathogens in laboratory settings.
      • Measurement of RNA stability and duration of effect.
2. Establishment of Mass Production Methods
   1. Scaling Up Production Processes
      • Transition from lab scale to pilot scale.
      • Design and optimization of bioreactors.
   2. Optimization of Production Conditions
      • Optimization of culture media and conditions for MV production.
      • Improvement of production efficiency and yield.
3. Safety Testing and Pesticide Registration Application
   1. Conducting Safety Tests
      • Implementation of the aforementioned tests.
   2. Submission of Pesticide Registration Application
      • Preparation of application documents based on each country’s pesticide registration system.
      • Responding to the review process and providing additional information.
4. Commencement of Sales
   1. Marketing and Promotion
      • Identification and segmentation of target markets.
      • Deployment of brand strategies and promotional activities.
   2. Building Sales Channels
      • Conclusion of contracts with sales agents and distributors.
      • Utilization of online sales platforms.
   3. Start of Production
      • Establishment of MOVE production facilities.
      • Commencement of production.
5. Market Expansion
   1. Development of New Products
      • Development of RNA sequences targeting new pests and pathogens.
      • Consideration of integrated products with other agricultural materials.
   2. Entry into International Markets
      • Researching overseas regulatory requirements and obtaining approvals.
      • Building an international sales network.

Risks and Countermeasures

In the MOVE project, various risks are anticipated in the practical application of RNA pesticides. First, there are safety concerns regarding impacts on non-target organisms. To address this, we will conduct detailed impact assessments and ecosystem monitoring, establishing safe usage guidelines.

As a regulatory risk, obtaining approval may become challenging due to differences in laws and regulations across countries and regions. We will mitigate this by collaborating with regulatory authorities from an early stage and preparing the necessary data.

Technical risks include challenges during large-scale production. We will overcome these by optimizing production processes, training specialists, and collaborating with industry partners.

Economic risks involve the possibility of increased production costs burdening farmers. We will ensure economic feasibility by improving production efficiency, implementing cost-reduction measures, and utilizing subsidies.

Acceptance risks stem from skepticism among farmers and consumers toward new technologies. We will deepen understanding and build trust through education and demonstrations.

Other risks include intellectual property issues, biosecurity, development of resistance, and long-term environmental impacts. For each risk, we will take appropriate measures based on expert advice to enhance the success and sustainability of the project.