Rose Flavone

Relieve Neurodegenerative diseases
caused by staying up late biomarkers.

Current Problem

Staying up late has become a major health problem in the contemporary society. Statistically, only 29% people go to bed before 23:00, 47% go to bed after midnight, and 13% do not go to bed until 2:00 a.m. in the morning. For Chinese college students, 57.96% often stay up late, 38.97% occasionally stay up late, and only 3.07% do not stay up late.[1]

Neurodegenerative diseases,such as Alzheimer's disease and Parkinson's disease, are conditions that lead to progressive injury of nerve cells, thus is irreversible. The risk of suffering from neurodegenrative diseases increases as a person gets older.[2]

Increasing evidence has revealed that circadian and sleep disturbances are not only symptoms of many neurodegenerative diseases but may actually drive pathological processes in the early stages of these diseases.[3]

In 2023, the market size of health tea in China was 41.16 billion yuan, with a growth of 27.3% compared with 2022; the health tea product category presents a diversified trend, and 45.9% of consumers chose health tea bags for tea brewing. [4]

Prevalent health products: Compound vitamin supplements, OMEGA-3 fish oil supplements, Glucosamine supplements, Probiotic supplements, Compound vitamin B miscellaneous, Collagen supplements

The overall consumption experience of health products is poor. Main reasons: lack of efficacy, high price, and hidden side effects.

Our Solution

Flavonoid compounds have a wide range of biological activities that reduce oncogene expression,
which indirectly protect nerves.[5] Flavonoids in rose protect cells from oxidative damage,
reducing risk of health disorders that mimic dementia symptoms (especially Alzheimer's disease)[6]

Reference

[1]The Chinese Sleep Research Society, the 2024 Chinese National Healthy Sleep White Paper.
[2]Lamptey RNL, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J. A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics. Int J Mol Sci. 2022 Feb 6;23(3):1851. doi: 10.3390/ijms23031851. PMID: 35163773; PMCID: PMC8837071.
[3] Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol. 2019 Mar;18(3):307-318. doi: 10.1016/S1474-4422(18)30461-7. Epub 2019 Feb 12. PMID: 30784558; PMCID: PMC6426656.
[4] iiMedia Research, 2024 China Health Herbal Beverage Industry Status Research and Consumer Insight Report, https://www.iimedia.cn/c1020/101636.html
[5] Zhiguo Zhang, Meilin Wang, Shu Xing, Chen Zhang, Flavonoids of Rosa rugosa Thunb. inhibit tumor proliferation and metastasis in human hepatocellular carcinoma HepG2 cells, Food Science and Human Wellness, Volume 11, Issue 2, 2022,Pages 374-382,
ISSN 2213-4530, https://doi.org/10.1016/j.fshw.2021.11.016.
[6]Stanley I.R. Okoduwa, Ibrahim Abdulwaliyu, Bernard E. Igiri, Shefiat O. Arekemase, Ugochi J. Okoduwa, Joseph F. Itiat, Mercy N. Egbule, Razaq A. Mustapha, Multi-therapeutic potential of flavonoids as an essential component in nutraceuticals for the treatment and management of human diseases, Phytomedicine Plus, Volume 4, Issue 2, 2024, 100558, ISSN 2667-0313, https://doi.org/10.1016/j.phyplu.2024.100558.

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