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Multi-stage signal amplification combined with single-molecule platform for tumor marker detection
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We have constructed a universal detection platform for nucleic acid markers based on the classifiers of DNA integrated circuits - polymerase self-enhancement and CRISPR two-step reaction, which can accurately translate nucleic acid signals into intuitive one-dimensional results for precise diagnosis of diseases.

PCR-free
Highly Accurate
Adjustable sensitivity
microRNA
MicroRNAs are important intracellular molecular components that play key roles in both normal and pathological states, and have received particular attention in cancer research. Numerous studies have shown that microRNAs play important roles in cancer proliferation, apoptosis, invasion, metastasis, and genomic instability by regulating the expression of their target mRNAs. Compared with biomarkers such as mRNAs or proteins, microRNAs are more stable in blood and less prone to degradation, making them more suitable as markers for in vitro detection. Therefore, we chose microRNA as a biomarker for accurate disease detection.

MicroRNA
Detection platform target

DNAMolecularProbes
DNA molecular probes, as programmable polymers capable of storing and processing information ranging from logic circuits to neural networks, enabling versatile computational devices for detecting, isolating, or identifying specific nucleic acid sequences of interest, show encouraging promise in biomolecular diagnostics in the medical field.

DNA molecular probes
Substances that build the detection platform

TotalInternal
Based on the phenomenon of total internal reflection of light, the device is capable of high-resolution imaging of the surface area of the sample, displaying the fluorescence signal generated by the reaction as a single-molecule fluorescence map, and then processing the image with our designed program to obtain diagnostic results in an automated manner.

Total internal reflection fluorescence microscope
Substances that build the detection platform

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