"There was a strange stillness. The birds, for example — where had they gone? Many people spoke of them, puzzled and disturbed. The feeding stations in the backyards were deserted. The few birds seen anywhere were moribund; they trembled violently and could not fly. It was a spring without voices, only silence lay over the fields, woods, and marsh."

—— Silent Spring written by Rachel Carson

Silent Spring depicts the environmental pollution and ecological damage caused by excessive use of chemicals and fertilizers, ultimately leading to unbearable disasters for humanity.

Are you worried that the phenomena described in the book will become a reality?

After the publication of the book, people were surprised to find that the words written in it were turning into reality. A series of strange and inexplicable phenomena began to appear all over the world. Many reports about animals and humans are worrying: abnormal behavior, decreased reproductive capacity, and death of young.

A dangerous class of chemicals is harming environmental health - environmental endocrine disruptors: (refers to exogenous chemical substances released into the environment by human production and life that affect the normal hormone levels in the bodies of humans and animals.)

Many familiar pesticides and material additives belong to environmental endocrine disruptors, and in fact, there are even more endocrine disruptors lurking around us...

And it is our task to find out these substances.

The important mechanism of action of environmental endocrine disruptors in living organisms is to bind to hormone receptors, thereby disrupting the regulation of hormones. We will start from this binding effect to find a way to detect the endocrine disruptor effect.

But that is not enough,

The action of environmental endocrine disruptors in living organisms is complex and involves multiple effects. Therefore, we will use the HRP and luxR/I system to construct an AND gate detection circuit and combine it with other toxic effects to achieve a more comprehensive and detailed detection and evaluation of environmental endocrine disruptors.